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In cooperation with the Department of Microbiology, several new microbial iron chelators
(siderophores) were isolated, purified and their structures were determined.
Different metal
complexes of the carboxylate siderophore rhizoferrin
were prepared and analyzed.
Receptor-binding and transportation properties in
enterobacteriaceae
and
zygomycetes
were
studied using biosynthetic derivatives and
3
H-labeled rhizoferrin. 3D structures of gallium
complexes were calculated on the basis of NMR-derived conformational constraints.
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1. S. Konetschny-Rapp, G. Jung, J. Meiwes, and H. Zähner (1990).
Staphyloferrin A: A Structurally New Siderophore from Staphylococci,
Eur. J. Biochem. 191, 65-74.
2. S. Konetschny-Rapp, G. Jung, K. N. Raymond, J. Meiwes, and H. Zähner
(1992).
Solution Thermodynamics of the Ferric Complexes of New Desferrioxamine
Siderophores Obtained by Directed Fermentation,
J. Am. Chem. Soc. 114,
529-534.
3. H.Drechsel, G.Jung, and G.Winkelmann (1992).
Stereochemical Characterization of Rhizoferrin and Identification of its Dehydration
Products,
Biometals 5, 141-148.
4. H.Stephan, S.Freund, J.-M.Meyer, G.Winkelmann, and G.Jung (1993).
Structure Elucidation of the Gallium-Ornibactin Complex by 2D-NMR
Spectroscopy,
Liebigs Ann. Chem. 1993, 43-48.
5. H. Stephan, S. Freund, W. Beck, G. Jung, J.-M. Meyer, and G. Winkelmann
(1993).
Ornibactins - a New Family of Siderophores from
Pseudomonas,
Biometals 6, 93-100.
6. H. Drechsel, S. Freund, G. Nicholson, H. Haag, O. Jung, H. Zähner, and G.
Jung (1993).
Purification and Chemical Characterization of Staphyloferrin B, a Hydrophilic
Siderophore from Staphylococci,
BioMetals 6, 185-192.
7. G. Winkelmann, A. Cansier, W. Beck, and G. Jung (1994).
HPLC Separation of Enterobactin and Linear 2,3-Dihydroxybenzylserine Derivatives:
A Study on Mutants of
Escherichia coli
Defective in Regulation
(fur), Esterase (fes) and Transport (fep A),
BioMetals 7, 149-154.
8. H. Drechsel, M. Tschierske, A. Thieken, G. Jung, H. Zähner, and G. Winkel-
mann (1995).
The Carboxylate Type Siderophore Rizoferrin and its Analogs Produced by
Directed Fermentation,
J. Industrial Microbiol. 14, 105-112.
9. H. Drechsel, H. Stephan, R. Lotz, H. Haag, H. Zähner, K. Hantke, and G. Jung
(1995).
Structure Elucidation of Yersiniabactin, a Siderophore from Highly Virulent
Yersinia
Strains,
Liebigs Ann. Chem. 1995, 1727-1733.
10. M. Jakobi, G. Winkelmann, D. Kaiser, C. Kempter, G. Jung, G. Berg, and H. Bahl (1996)
Maltophilin: a New Antifungal Compound Produced by
Stenotrophomonas maltophilia
R3089
J. Antibiot. 49, 1101-1104.
11. C. Carrano, H. Drechsel, D. Kaiser, G. Jung, B. Matzanke, G. Winkelmann, N. Rochel, and
A.M. Albrecht-Gary (1996)
Coordination Chemistry of the Carboxylate Type Siderophore Rhizoferrin: The Iron(III) Complex
and Its MEtal Analogs,
Inorg. Chem. 35, 6429-6436.
12. M. Tschierske, H. Drechsel, G. Jung, and H. Zaehner (1996)
Production of Rhizoferrin and New Analogs Obtained by Directed Fermentation,
Appl. Microbiol. Biotechnol. 45, 664-670.
13. H. Stephan, C. Kempter, J.W. MEtzger, G. Jung, O. Potterat, C. Pfefferle, and H.P. Fiedler (1996)
Kanchanamycins, New Polyol Macrolide Antibiotics Produced by
Streptomyces olivaceus
Tü 4018,
II. Structure Elucidation,
J. Antibiot. 49, 765-769.
14. C. Kempter, D. Kaiser, S. Haag, G. Nicholson, V. Gnau, T. Walk, K.-H. Gierling, H. Decker, H. Zaehner,
G. Jung, and J.W. Metzger (1997)
CDA: A Calcium-Dependent Peptide Antibiotic from
Streptomyces coelicolor
A3(2) Containing Unusual
Residues,
Angew. Chem. 109, 510-513; Angew. Chem. Int. Ed. Engl. 36, 498-501.